CIENCIA

Científicas son galardonadas con el premio Nobel de Química por su trabajo en el genoma.

La Real Academia Sueca de Ciencias otorgó hace unos días el Premio Nobel de Química 2020 a Emmanuelle Charpentier y Jennifer Doudna por su trabajo en CRISPR (clustered regularly interspaced short palindromic repeats, en español repeticiones palindrómicas cortas agrupadas y regularmente interespaciadas) un método de manipulación y edición del genoma (Conjunto formado por el material genético del ADN de los cromosomas y de las mitocondrias).

Un genoma es el conjunto completo de instrucciones genéticas que determinan cómo se desarrollará un organismo. Con CRISPR, los investigadores pueden cortar el ADN del genoma de un organismo y editar su secuencia.

Emmanuelle Charpentier, left, and Jennifer A. Doudna in Oviedo, Spain, in 2015.
Foto: AFP.

La tecnología CRISPR es una fuente inagotable de investigación básica y también está cambiando el mundo en el que vivimos. Cada año se publican miles de artículos de investigación sobre sus diversas aplicaciones.

Estos incluyen acelerar la investigación sobre cánceres, enfermedades mentales, trasplantes potenciales de órganos de animales a humanos, mejor producción de alimentos, eliminar los mosquitos portadores de malaria y salvar a los animales de enfermedades.

CRISPR – ChileBIO

Charpentier es la directora del Instituto Max Planck de Biología de Infecciones en Berlín, Alemania y Doudna es profesora en la Universidad de California, Berkeley. Ambas tuvieron un papel crucial en la demostración de cómo CRISPR podría usarse en secuencias de ADN de interés.

La tecnología CRISPR está adaptada de un sistema que está naturalmente presente en bacterias y otros organismos unicelulares conocidos como arqueas.

Charpentier y Doudna, descubridoras de las tijeras géneticas CRISPR, ganan el Premio Nobel de Química
Foto: agenciasinc.es

Este sistema natural le da a las bacterias una forma de inmunidad adquirida. Los protege de elementos genéticos extraños (como virus invasores) y les permite recordarlos en caso de que reaparezcan.

Como la mayoría de los avances en la ciencia moderna, el descubrimiento de CRISPR y su aparición como un método clave en la edición del genoma implicó los esfuerzos de muchos investigadores durante varias décadas.

Hoy, CRISPR es la herramienta de edición de genes preferida por miles de investigadores.

Rompecabezas, Adn, Investigación, Genética, Pieza, 3D

Una revolución técnica con infinitas aplicaciones

Los humanos han alterado los genomas de las especies durante miles de años. Inicialmente, esto se hizo a través de enfoques como la cría selectiva.

Sin embargo, la ingeniería genética, la manipulación directa del ADN por parte de los humanos fuera de la reproducción y las mutaciones, solo existe desde la década de 1970.

Los sistemas basados ​​en CRISPR cambiaron fundamentalmente este campo, ya que permiten editar genomas en organismos vivos de forma económica, fácil y con extrema precisión.

Hombre, Adn, Espiral, Biología, Fundirse, Puntos

CRISPR actualmente está teniendo un gran impacto en la salud. Existen ensayos clínicos sobre su uso para trastornos sanguíneos, para el tratamiento de la causa más común de ceguera infantil hereditaria (amaurosis congénita de Leber) y para la inmunoterapia del cáncer.

CRISPR también tiene un gran potencial en la producción de alimentos. Se puede utilizar para mejorar la calidad del cultivo, el rendimiento, la resistencia a las enfermedades y a los herbicidas.

Utilizado en el ganado, puede conducir a una mejor resistencia a las enfermedades, un mayor bienestar animal y mejores características productivas, es decir, animales que producen más carne, leche o lana de alta calidad.

Adn, La Biología, Medicina, Gen, Microbiología

Sin embargo, persisten varios desafíos para la tecnología. Algunos son técnicos, como el riesgo de modificaciones fuera del objetivo (que ocurren cuando Cas9 corta en ubicaciones no deseadas en el genoma).

Otros problemas son sociales. CRISPR se usó en uno de los experimentos más controvertidos de los últimos años.

El biofísico chino He Jiankui intentó sin éxito utilizar la tecnología para modificar embriones humanos y hacerlos resistentes al VIH (virus de inmunodeficiencia humana). Esto llevó al nacimiento de las gemelas Lulu y Nana.

Esqueleto Humano, Cuerpo Humano, Anatomía, Rayos X

Necesitamos un debate amplio e inclusivo sobre la regulación de estas tecnologías, especialmente por su potencial y amplitud.

Somos Extremo Mundial.

Con información de The Conversation.

57 thoughts on “Científicas son galardonadas con el premio Nobel de Química por su trabajo en el genoma.

  • Thank you for another informative website. The place else could I am
    getting that kind of information written in such a perfect approach?
    I’ve a challenge that I am simply now working on, and I’ve been on the glance out for such info.

    Respuesta
  • I pay a visit every day some sites and sites to read articles or
    reviews, however this website gives quality based
    posts.

    Respuesta
  • With havin so much written content do you ever run into
    any problems of plagorism or copyright infringement?
    My blog has a lot of unique content I’ve either written myself or
    outsourced but it appears a lot of it is popping it up all over the internet without my permission. Do you know any methods to help prevent content from being stolen? I’d genuinely appreciate
    it.

    Respuesta
  • I do consider all of the concepts you’ve introduced on your post.

    They are really convincing and will definitely work. Still, the posts are very short for newbies.
    May just you please prolong them a little from subsequent time?
    Thank you for the post.

    Respuesta
  • Thanks for sharing such a fastidious thought, paragraph is nice,
    thats why i have read it entirely

    Respuesta
  • It’s perfect time to make some plans for the longer term and it is time to be happy.

    I’ve read this publish and if I could I desire to
    recommend you few fascinating things or advice. Maybe you could write
    subsequent articles referring to this article. I desire to
    learn even more issues about it!

    Respuesta
  • Amazing! This blog looks exactly like my old one!
    It’s on a completely different subject but it has pretty much the
    same layout and design. Outstanding choice of colors!

    Respuesta
  • Oh my goodness! Amazing article dude! Thank you, However I am having difficulties with your RSS. I don’t know the reason why I cannot join it. Is there anyone else getting the same RSS issues? Anyone who knows the solution can you kindly respond? Thanks!!

    Respuesta
  • I love reading through an article that will make people
    think. Also, many thanks for allowing for me to comment!

    Respuesta
  • Thhe name Baccarat is French, but, ass previously described, the
    game finds it roots in Italy when the game was introduced in the late 15th century under the name Baccara.

    Feel free to visit my page … web page

    Respuesta
  • The sector is major andd grows with each and every passing
    day, so staying afloat can be a challenge ffor inexperienced punters.

    Also visit my site Casino Bonus

    Respuesta
  • From the moment you arrive, you will be respected andd encouraged to be oneself.

    Feel free to visit my website: site

    Respuesta
  • They hardly ever impose costs and may possibly be able to save you
    from oerdraft charges and other consequences for exceeding
    your amount.

    Feel frdee to surf to my web site :: 신용대출

    Respuesta
  • He earned All-Mid-American Conference second-group honors as a Ball State senior inn
    2013.

    My web-site: homepage

    Respuesta
  • In the under list, I’ve rounded up the major UK internet sites for football betting.

    Also vvisit my web sife … toto79.org

    Respuesta
  • Harry Potter author JK Rowling, who has been criricised
    for her persnal beliefs on the subject, was
    among these sending messages of support
    onn social media.

    my web site ezalba.co.kr

    Respuesta
  • This article is genuinely a pleasant one it
    assists new internet people, who are wishing for blogging.

    Respuesta
  • I’ll immediately snatch your rss feed as I can’t in finding your
    email subscription hyperlink or newsletter service.
    Do you’ve any? Please let me recognize so that I may subscribe.
    Thanks.

    Respuesta
  • Howdy! This is my first visit to your blog! We are a team of volunteers and starting a new initiative in a community in the same niche.

    Your blog provided us valuable information to work on. You have done a
    outstanding job!

    Respuesta
  • Nice post. I was checking constantly this blog and
    I am inspired! Extremely useful info specifically the last section 🙂 I take
    care of such information much. I was seeking
    this particular information for a long time. Thank you and good luck.

    Respuesta
  • Asking questions are truly pleasant thing if you are not understanding
    anything completely, except this piece of writing provides nice
    understanding even.

    Respuesta
  • This is a topic that is near to my heart… Cheers!
    Exactly where are your contact details though?

    Respuesta
  • Hey There. I found your weblog using msn. This is
    a really smartly written article. I’ll make sure to bookmark it and
    return to learn more of your useful info. Thanks for
    the post. I’ll certainly comeback.

    Respuesta
  • Hello would you mind letting me know which hosting company you’re working with?
    I’ve loaded your blog in 3 different browsers and I must say this blog loads a lot faster
    then most. Can you recommend a good web hosting provider at a fair price?

    Thanks a lot, I appreciate it!

    Respuesta
  • Howdy! This post couldn’t be written any better!
    Reading through this post reminds me of my previous roommate!
    He constantly kept preaching about this. I will send this post to him.
    Fairly certain he will have a very good read. Thanks for sharing!

    Respuesta
  • Whats up very nice site!! Guy .. Excellent .. Wonderful ..

    I will bookmark your site and take the feeds additionally?

    I’m glad to find numerous useful info here in the put up,
    we’d like work out more strategies in this regard, thanks for sharing.

    . . . . .

    Respuesta
  • Hello there, just became aware of your blog through Google, and found that it is truly informative.

    I’m going to watch out for brussels. I’ll appreciate if you continue this in future.
    Numerous people will be benefited from your writing.
    Cheers!

    Respuesta
  • Hello, I log on to your new stuff regularly. Your writing style
    is awesome, keep it up!

    Respuesta
  • Howdy just wanted to give you a quick heads up.
    The words in your article seem to be running off the screen in Ie.
    I’m not sure if this is a format issue or something to do
    with internet browser compatibility but I figured I’d post to let
    you know. The style and design look great though!
    Hope you get the issue resolved soon. Cheers

    Respuesta
  • Right away I am going to do my breakfast, afterward having my breakfast coming yet
    again to read more news.

    Respuesta
  • Excellent beat ! I wish to apprentice while you amend your web site, how could i subscribe for a blog website?
    The account helped me a acceptable deal. I had been a little bit acquainted of this your broadcast offered bright clear idea

    Respuesta
  • Howdy, i read your blog occasionally and i own a similar one and i was
    just curious if you get a lot of spam remarks? If
    so how do you prevent it, any plugin or anything you
    can recommend? I get so much lately it’s driving me insane so any assistance is very much appreciated.

    Respuesta
  • Hi, I think your website might be having browser compatibility issues.
    When I look at your blog in Safari, it looks fine but when opening in Internet Explorer, it has
    some overlapping. I just wanted to give you a quick heads up!
    Other then that, amazing blog!

    Respuesta
  • Somebody necessarily help to make seriously posts I’d state.
    That is the first time I frequented your website page and so far?
    I surprised with the research you made to make this particular put up amazing.

    Great activity!

    Respuesta
  • Do you have a spam problem on this website; I also
    am a blogger, and I was wanting to know your situation; many of us
    have developed some nice practices and we are looking to exchange strategies with other folks, why not shoot me an e-mail if interested.

    Respuesta
  • This is a really good tip particularly to those new to the blogosphere.

    Simple but very accurate info… Thanks for sharing this one.

    A must read article!

    Respuesta
  • Someone necessarily assist to make significantly articles I would state.
    That is the very first time I frequented your web
    page and thus far? I surprised with the analysis you made to
    make this actual publish extraordinary. Great process!

    Respuesta
  • Aw, this was an exceptionally good post. Spending some time and
    actual effort to generate a superb article… but what can I say… I procrastinate a lot
    and don’t seem to get anything done.

    Respuesta
  • Good day! I could have sworn I’ve visited this blog before but after looking
    at some of the posts I realized it’s new to me.
    Regardless, I’m certainly pleased I stumbled upon it and I’ll be bookmarking it and
    checking back often!

    Respuesta
  • If some one wants to be updated with latest technologies afterward he must
    be pay a quick visit this web site and be up to date daily.

    Respuesta

Deja una respuesta

Tu dirección de correo electrónico no será publicada. Los campos obligatorios están marcados con *